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Assay Detail

CHEMBL819306

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human platelet c-AMP phosphodiesterase PDE 3
ChEMBL ↗
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Phosphodiesterase 3 (CHEMBL2094125) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility.
Meanwell NA, Dennis RD, Roth HR, Rosenfeld MJ, Smith EC, Wright JJ, Buchanan JO, Brassard CL, Gamberdella M, Gillespie E.
J Med Chem (1992) 35 : 2688 -2696
PubMed 1321911 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 57 8.33 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL327234 — — 1 10.52
CHEMBL88787 — — 1 10.10
CHEMBL90877 — — 1 9.70
CHEMBL329173 — — 1 9.70
CHEMBL90647 — — 1 9.52
CHEMBL328543 — — 1 9.52
CHEMBL91503 — — 1 9.52
CHEMBL91388 — — 1 9.40
CHEMBL432057 — — 1 9.40
CHEMBL329788 — — 1 9.40
CHEMBL92165 — — 1 9.30
CHEMBL91088 — — 1 9.22
CHEMBL91715 — — 1 9.22
CHEMBL330086 — — 1 9.15
CHEMBL329573 — — 1 9.15
CHEMBL90876 — — 1 9.15
CHEMBL433183 — — 1 9.15
CHEMBL431085 — — 1 9.15
CHEMBL91014 — — 1 9.05
CHEMBL91249 — — 1 9.05
CHEMBL313021 — — 1 9.00
CHEMBL90176 — — 1 9.00
CHEMBL93730 — — 1 8.70
CHEMBL330737 — — 1 8.70
CHEMBL89810 — — 1 8.70
CHEMBL92205 — — 1 8.70
CHEMBL90546 — — 1 8.70
CHEMBL90380 — — 1 8.52
CHEMBL327882 — — 1 8.52
CHEMBL328711 — — 1 8.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL327234 — IC50 = 0.03 nM 10.52
CHEMBL88787 — IC50 = 0.08 nM 10.10
CHEMBL329173 — IC50 = 0.2 nM 9.70
CHEMBL90877 — IC50 = 0.2 nM 9.70
CHEMBL90647 — IC50 = 0.3 nM 9.52
CHEMBL328543 — IC50 = 0.3 nM 9.52
CHEMBL91503 — IC50 = 0.3 nM 9.52
CHEMBL91388 — IC50 = 0.4 nM 9.40
CHEMBL432057 — IC50 = 0.4 nM 9.40
CHEMBL329788 — IC50 = 0.4 nM 9.40
CHEMBL92165 — IC50 = 0.5 nM 9.30
CHEMBL91088 — IC50 = 0.6 nM 9.22
CHEMBL91715 — IC50 = 0.6 nM 9.22
CHEMBL431085 — IC50 = 0.7 nM 9.15
CHEMBL329573 — IC50 = 0.7 nM 9.15
CHEMBL90876 — IC50 = 0.7 nM 9.15
CHEMBL330086 — IC50 = 0.7 nM 9.15
CHEMBL433183 — IC50 = 0.7 nM 9.15
CHEMBL91014 — IC50 = 0.9 nM 9.05
CHEMBL91249 — IC50 = 0.9 nM 9.05
CHEMBL313021 — IC50 = 1.0 nM 9.00
CHEMBL90176 — IC50 = 1.0 nM 9.00
CHEMBL90546 — IC50 = 2.0 nM 8.70
CHEMBL92205 — IC50 = 2.0 nM 8.70
CHEMBL330737 — IC50 = 2.0 nM 8.70
CHEMBL93730 — IC50 = 2.0 nM 8.70
CHEMBL89810 — IC50 = 2.0 nM 8.70
CHEMBL90380 — IC50 = 3.0 nM 8.52
CHEMBL327882 — IC50 = 3.0 nM 8.52
CHEMBL328711 — IC50 = 4.0 nM 8.40
CHEMBL90515 — IC50 = 4.5 nM 8.35
CHEMBL89820 — IC50 = 5.0 nM 8.30
CHEMBL92169 — IC50 = 5.0 nM 8.30
CHEMBL327786 — IC50 = 6.0 nM 8.22
CHEMBL90230 — IC50 = 7.0 nM 8.15
CHEMBL91010 — IC50 = 7.0 nM 8.15
CHEMBL329412 — IC50 = 7.0 nM 8.15
CHEMBL327808 — IC50 = 8.0 nM 8.10
CHEMBL314949 — IC50 = 9.0 nM 8.05
CHEMBL88583 — IC50 = 13.0 nM 7.89
CHEMBL329248 — IC50 = 20.0 nM 7.70
CHEMBL328279 — IC50 = 20.0 nM 7.70
CHEMBL88182 — IC50 = 20.0 nM 7.70
CHEMBL92202 — IC50 = 30.0 nM 7.52
CHEMBL90183 — IC50 = 30.0 nM 7.52
CHEMBL92381 — IC50 = 40.0 nM 7.40
CHEMBL91724 — IC50 = 40.0 nM 7.40
CHEMBL330240 — IC50 = 40.0 nM 7.40
CHEMBL329344 — IC50 = 50.0 nM 7.30
CHEMBL88797 — IC50 = 80.0 nM 7.10