Assay Detail
Binding
CHEMBL819311
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Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.59 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.30 |
| CHEMBL35048 | — | — | 1 | 4.89 |
| CHEMBL36290 | — | — | 1 | 4.80 |
| CHEMBL416770 | — | — | 1 | 4.75 |
| CHEMBL285663 | — | — | 1 | 4.66 |
| CHEMBL439920 | — | — | 1 | 4.62 |
| CHEMBL18701 | RO-201724 | — | 1 | 4.58 |
| CHEMBL288553 | — | — | 1 | 4.52 |
| CHEMBL32139 | — | — | 1 | 4.50 |
| CHEMBL284512 | — | — | 1 | 4.47 |
| CHEMBL32155 | — | — | 1 | 4.34 |
| CHEMBL9175 | — | — | 1 | 4.28 |
| CHEMBL289253 | — | — | 1 | 4.02 |
| CHEMBL284399 | — | — | 1 | - |
| CHEMBL284081 | — | — | 1 | - |
| CHEMBL32226 | — | — | 1 | - |
| CHEMBL35958 | — | — | 1 | - |
| CHEMBL286419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL35048 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL36290 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL416770 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL285663 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL439920 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL18701 | RO-201724 | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL288553 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL32139 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL284512 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL32155 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL9175 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL289253 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL284399 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL284081 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL32226 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL35958 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL286419 | — | IC50 | > | 1000000.0 | nM | - |