Assay Detail
Binding
CHEMBL819321
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Inhibition of human blood platelet c-AMP phosphodiesterase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.21 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL760 | ANAGRELIDE | 4.0 | 1 | 7.09 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL760 | ANAGRELIDE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 4700.0 | nM | 5.33 |