Assay Detail
Functional
CHEMBL819349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro cytotoxicity against human breast cancer cell line (SK-BR-3)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.40 |
| CHEMBL289665 | — | — | 1 | 7.89 |
| CHEMBL445883 | — | — | 1 | 7.80 |
| CHEMBL296862 | — | — | 1 | 7.77 |
| CHEMBL44044 | — | — | 1 | 7.72 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.70 |
| CHEMBL297811 | — | — | 1 | 7.60 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.58 |
| CHEMBL288053 | — | — | 1 | 6.97 |
| CHEMBL41652 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL289665 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL445883 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL296862 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL44044 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL297811 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL288053 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL41652 | — | IC50 | = | 417.0 | nM | 6.38 |