Assay Detail
Binding
CHEMBL819364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.24 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368329 | — | — | 1 | 6.40 |
| CHEMBL367169 | — | — | 1 | 6.00 |
| CHEMBL174214 | — | — | 1 | 5.68 |
| CHEMBL172296 | — | — | 1 | 5.64 |
| CHEMBL174004 | — | — | 1 | 5.52 |
| CHEMBL176459 | — | — | 1 | 5.47 |
| CHEMBL177033 | — | — | 1 | 5.46 |
| CHEMBL176933 | — | — | 1 | 5.42 |
| CHEMBL366328 | — | — | 1 | 5.25 |
| CHEMBL176571 | — | — | 1 | 5.24 |
| CHEMBL176426 | — | — | 1 | 5.22 |
| CHEMBL366868 | — | — | 1 | 5.09 |
| CHEMBL368204 | — | — | 1 | 5.02 |
| CHEMBL172806 | — | — | 1 | 4.96 |
| CHEMBL172854 | — | — | 1 | 4.85 |
| CHEMBL367700 | — | — | 1 | 4.80 |
| CHEMBL172090 | — | — | 1 | 4.66 |
| CHEMBL174457 | — | — | 1 | 4.52 |
| CHEMBL366871 | — | — | 1 | 4.43 |
| CHEMBL367246 | — | — | 1 | - |
| CHEMBL174304 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368329 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL367169 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL174214 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL172296 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL174004 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL176459 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL177033 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL176933 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL366328 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL176571 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL176426 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL366868 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL368204 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL172806 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL172854 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL367700 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL172090 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL174457 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL366871 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL367246 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL174304 | — | Ki | > | 10000.0 | nM | - |