Assay Detail
Binding
CHEMBL819376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.45 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543854 | — | — | 1 | 6.22 |
| CHEMBL93603 | — | — | 1 | 6.16 |
| CHEMBL96731 | — | — | 1 | 5.89 |
| CHEMBL314290 | — | — | 1 | 5.89 |
| CHEMBL329903 | — | — | 1 | 5.85 |
| CHEMBL96255 | — | — | 1 | 5.85 |
| CHEMBL327242 | — | — | 1 | 5.80 |
| CHEMBL329026 | — | — | 1 | 5.72 |
| CHEMBL329141 | — | — | 1 | 5.72 |
| CHEMBL328079 | — | — | 1 | 5.70 |
| CHEMBL432043 | — | — | 1 | 5.47 |
| CHEMBL330016 | — | — | 1 | 5.38 |
| CHEMBL49429 | LIXIVAPTAN | 3.0 | 1 | 5.22 |
| CHEMBL94133 | — | — | 1 | 5.19 |
| CHEMBL327365 | — | — | 1 | 5.10 |
| CHEMBL330094 | — | — | 1 | 4.96 |
| CHEMBL539285 | — | — | 1 | 4.85 |
| CHEMBL330494 | — | — | 1 | 4.85 |
| CHEMBL2093899 | — | — | 1 | 4.85 |
| CHEMBL93366 | — | — | 1 | 4.85 |
| CHEMBL421180 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543854 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL93603 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL96731 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL314290 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL329903 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL96255 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL327242 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL329026 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL329141 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL328079 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL432043 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL330016 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL49429 | LIXIVAPTAN | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL94133 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL327365 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL330094 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL539285 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL330494 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL2093899 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL93366 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL421180 | — | Ki | = | 14000.0 | nM | 4.85 |