Assay Detail
Binding
CHEMBL819557
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Inhibition of Vascular endothelial growth factor receptor in 3T3 cells
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.90 | 7.40 |
| NT | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13983 | — | — | 1 | 7.40 |
| CHEMBL268731 | — | — | 1 | 7.30 |
| CHEMBL13354 | — | — | 1 | 7.30 |
| CHEMBL13485 | SU-11652 | — | 1 | 7.30 |
| CHEMBL13629 | — | — | 1 | 7.30 |
| CHEMBL13608 | TOCERANIB | 2.0 | 1 | 7.30 |
| CHEMBL13976 | — | — | 1 | 7.30 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.30 |
| CHEMBL267293 | — | — | 1 | 6.30 |
| CHEMBL275117 | — | — | 1 | 6.30 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.98 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 5.70 |
| CHEMBL430155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13983 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL268731 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL13354 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL13485 | SU-11652 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL13629 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL13608 | TOCERANIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL13976 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL535 | SUNITINIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL267293 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL275117 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL430155 | — | NT | - | — | - |