Assay Detail
Functional
CHEMBL819565
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Compound was tested for antiviral activity against the Vero cells infected with HSV-1.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.34 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 6.06 |
| CHEMBL146894 | — | — | 1 | 5.97 |
| CHEMBL146139 | — | — | 1 | 5.87 |
| CHEMBL343403 | — | — | 1 | 5.59 |
| CHEMBL146647 | — | — | 1 | 4.85 |
| CHEMBL148179 | — | — | 1 | 4.65 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL146894 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL146139 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL343403 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL146647 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL148179 | — | EC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 38500.0 | nM | 4.42 |