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Assay Detail

CHEMBL819681

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration to inhibit 50% of tubulin polymerization from bovine brain
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Antineoplastic agents. 379. Synthesis of phenstatin phosphate.
Pettit GR, Toki B, Herald DL, Verdier-Pinard P, Boyd MR, Hamel E, Pettit RK.
J Med Chem (1998) 41 : 1688 -1695
PubMed 9572894 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.17 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL276625 PHENSTATIN 1 6.00
CHEMBL10557 1 5.68
CHEMBL45348 1 5.50
CHEMBL10121 1 5.48
CHEMBL288980 1 5.44
CHEMBL295663 1 5.36
CHEMBL45049 1 4.96
CHEMBL47505 1 4.82
CHEMBL44914 1 4.82
CHEMBL45513 1 4.44
CHEMBL45622 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL276625 PHENSTATIN IC50 = 1000.0 nM 6.00
CHEMBL10557 IC50 = 2100.0 nM 5.68
CHEMBL45348 IC50 = 3200.0 nM 5.50
CHEMBL10121 IC50 = 3300.0 nM 5.48
CHEMBL288980 IC50 = 3600.0 nM 5.44
CHEMBL295663 IC50 = 4400.0 nM 5.36
CHEMBL45049 IC50 = 11000.0 nM 4.96
CHEMBL47505 IC50 = 15000.0 nM 4.82
CHEMBL44914 IC50 = 15000.0 nM 4.82
CHEMBL45513 IC50 = 36000.0 nM 4.44
CHEMBL45622 IC50 = 39000.0 nM 4.41