Assay Detail
Binding
CHEMBL819711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding to human alphaV-beta3 integrin
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent and selective alpha v beta 3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.49 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315956 | — | — | 1 | 8.85 |
| CHEMBL313045 | — | — | 1 | 8.44 |
| CHEMBL85196 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315956 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL313045 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL85196 | — | IC50 | = | 6.8 | nM | 8.17 |