Assay Detail
Binding
CHEMBL819716
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Inhibitory activity against vitronectin receptor (alpha V beta 3)
47
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective alphavbeta3 integrin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.94 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58367 | — | — | 1 | 10.00 |
| CHEMBL60770 | — | — | 1 | 9.52 |
| CHEMBL2373037 | — | — | 1 | 9.22 |
| CHEMBL58818 | — | — | 1 | 9.15 |
| CHEMBL58334 | — | — | 1 | 9.10 |
| CHEMBL57737 | — | — | 1 | 9.05 |
| CHEMBL58524 | — | — | 1 | 9.00 |
| CHEMBL417949 | — | — | 1 | 9.00 |
| CHEMBL59291 | — | — | 1 | 9.00 |
| CHEMBL59546 | — | — | 1 | 8.70 |
| CHEMBL58364 | — | — | 1 | 8.70 |
| CHEMBL292613 | — | — | 1 | 8.70 |
| CHEMBL2373038 | — | — | 1 | 8.70 |
| CHEMBL417066 | — | — | 1 | 8.52 |
| CHEMBL292199 | — | — | 1 | 8.52 |
| CHEMBL58847 | — | — | 1 | 8.52 |
| CHEMBL59013 | — | — | 1 | 8.40 |
| CHEMBL418307 | — | — | 1 | 8.22 |
| CHEMBL291520 | — | — | 1 | 8.22 |
| CHEMBL2373039 | — | — | 1 | 8.22 |
| CHEMBL57850 | — | — | 1 | 8.22 |
| CHEMBL299666 | — | — | 1 | 8.15 |
| CHEMBL58602 | — | — | 1 | 8.15 |
| CHEMBL58533 | — | — | 1 | 8.05 |
| CHEMBL58465 | — | — | 1 | 7.82 |
| CHEMBL58275 | — | — | 1 | 7.82 |
| CHEMBL58667 | — | — | 1 | 7.66 |
| CHEMBL291910 | — | — | 1 | 7.64 |
| CHEMBL301274 | — | — | 1 | 7.58 |
| CHEMBL56995 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58367 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL60770 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2373037 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL58818 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL58334 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL57737 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL58524 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL417949 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL59291 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL59546 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL58364 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL292613 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2373038 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL58847 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL417066 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL292199 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL59013 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL418307 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL291520 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2373039 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL57850 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL299666 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL58602 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL58533 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL58275 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL58465 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL58667 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL291910 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL301274 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL56995 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL57112 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL291669 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL59555 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL266151 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL58001 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL57771 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL58391 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL57245 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL58912 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL60926 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL430249 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL58219 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL60876 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL58763 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL57539 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL58763 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL57646 | — | IC50 | = | 1400.0 | nM | 5.85 |