Assay Detail
Binding
CHEMBL819720
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Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binding model for nonpeptide antagonists of alpha(v)beta(3) integrin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.28 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151142 | — | — | 1 | 10.40 |
| CHEMBL123262 | — | — | 1 | 10.15 |
| CHEMBL332914 | — | — | 1 | 10.10 |
| CHEMBL86992 | — | — | 1 | 9.82 |
| CHEMBL351105 | — | — | 1 | 9.46 |
| CHEMBL53822 | — | — | 1 | 8.06 |
| CHEMBL82927 | — | — | 1 | 6.96 |
| CHEMBL59562 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151142 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL123262 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL332914 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL86992 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL351105 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL53822 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL82927 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL59562 | — | IC50 | > | 1000.0 | nM | - |