Assay Detail
Binding
CHEMBL819722
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Inhibition of alphaV-beta3 interaction with vitronectin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411941 | CYCLORGDFV | — | 1 | 8.00 |
| CHEMBL141005 | — | — | 1 | 7.16 |
| CHEMBL343122 | — | — | 1 | 6.85 |
| CHEMBL343123 | — | — | 1 | 6.50 |
| CHEMBL2370493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL141005 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL343122 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL343123 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2370493 | — | IC50 | > | 10000.0 | nM | - |