Assay Detail
Binding
CHEMBL819934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against porcine trypsin was determined.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.82 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418839 | — | — | 1 | 7.96 |
| CHEMBL111543 | — | — | 1 | 7.89 |
| CHEMBL111338 | — | — | 1 | 7.41 |
| CHEMBL109367 | — | — | 1 | 7.38 |
| CHEMBL442201 | — | — | 1 | 7.37 |
| CHEMBL111471 | — | — | 1 | 7.29 |
| CHEMBL111575 | — | — | 1 | 7.25 |
| CHEMBL323387 | — | — | 1 | 7.24 |
| CHEMBL108447 | — | — | 1 | 7.09 |
| CHEMBL111567 | — | — | 1 | 7.04 |
| CHEMBL109535 | — | — | 1 | 6.94 |
| CHEMBL320749 | — | — | 1 | 6.63 |
| CHEMBL111432 | — | — | 1 | 6.58 |
| CHEMBL104937 | — | — | 1 | 6.49 |
| CHEMBL111660 | — | — | 1 | 5.88 |
| CHEMBL324168 | — | — | 1 | 5.68 |
| CHEMBL109287 | — | — | 1 | 5.58 |
| CHEMBL105171 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418839 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL111543 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL111338 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL109367 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL442201 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL111471 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL111575 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL323387 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL108447 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL111567 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL109535 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL320749 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL111432 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL104937 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL111660 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL324168 | — | Ki | = | 2080.0 | nM | 5.68 |
| CHEMBL109287 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL105171 | — | Ki | = | 7780.0 | nM | 5.11 |