Assay Detail
Functional
CHEMBL819936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS stimulated Tumor Necrosis Factor-alpha (TNF-alpha) release by human PBMC
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Thalidomide analogs and PDE4 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.77 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313439 | — | — | 1 | 6.92 |
| CHEMBL88475 | — | — | 1 | 6.16 |
| CHEMBL315529 | — | — | 1 | 5.80 |
| CHEMBL90345 | — | — | 1 | 5.80 |
| CHEMBL314759 | — | — | 1 | 5.77 |
| CHEMBL90349 | — | — | 1 | 5.62 |
| CHEMBL88153 | CDC-801 | 2.0 | 1 | 5.60 |
| CHEMBL419135 | — | — | 1 | 5.57 |
| CHEMBL88935 | — | — | 1 | 5.54 |
| CHEMBL89890 | — | — | 1 | 4.89 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313439 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL88475 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL315529 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL90345 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL314759 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL90349 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL88153 | CDC-801 | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL419135 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL88935 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL89890 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL468 | THALIDOMIDE | IC50 | ~ | 200000.0 | nM | - |