Assay Detail
Binding
CHEMBL819944
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In vitro inhibition of tumor necrosis factor-alpha converting enzyme
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96396 | — | — | 1 | 8.52 |
| CHEMBL94948 | — | — | 1 | 8.40 |
| CHEMBL94715 | — | — | 1 | 8.30 |
| CHEMBL94643 | — | — | 1 | 8.30 |
| CHEMBL316928 | — | — | 1 | 8.22 |
| CHEMBL316298 | — | — | 1 | 8.22 |
| CHEMBL92927 | — | — | 1 | 8.15 |
| CHEMBL321556 | — | — | 1 | 8.15 |
| CHEMBL328751 | — | — | 1 | 8.00 |
| CHEMBL96417 | — | — | 1 | 8.00 |
| CHEMBL94363 | — | — | 1 | 7.89 |
| CHEMBL94357 | — | — | 1 | 7.82 |
| CHEMBL317624 | — | — | 1 | 7.77 |
| CHEMBL96636 | — | — | 1 | 7.75 |
| CHEMBL98061 | — | — | 1 | 7.58 |
| CHEMBL94518 | — | — | 1 | 7.42 |
| CHEMBL96637 | — | — | 1 | 7.27 |
| CHEMBL96419 | — | — | 1 | 7.14 |
| CHEMBL94386 | — | — | 1 | 6.92 |
| CHEMBL97762 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96396 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL94948 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL94715 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL94643 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL316928 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL316298 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL92927 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL321556 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL328751 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL96417 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL94363 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL94357 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL317624 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL96636 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL98061 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL94518 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL96637 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL96419 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL94386 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL97762 | — | IC50 | = | 145.0 | nM | 6.84 |