Assay Detail
Functional
CHEMBL819946
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Inhibitory concentration against human solid tumor cell line DU145 prostate and HT-29 colon
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Tumor cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.49 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93426 | — | — | 1 | 7.54 |
| CHEMBL93217 | — | — | 1 | 7.52 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93426 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL93217 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 40.0 | nM | 7.40 |