Assay Detail
Functional
CHEMBL819949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF(tumor necrosis factor) in human blood
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 5.42 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344759 | — | — | 1 | 6.36 |
| CHEMBL144780 | — | — | 1 | 6.16 |
| CHEMBL144363 | — | — | 1 | 6.11 |
| CHEMBL144293 | — | — | 1 | 5.96 |
| CHEMBL144283 | — | — | 1 | 5.92 |
| CHEMBL357414 | — | — | 1 | 5.92 |
| CHEMBL356259 | — | — | 1 | 5.89 |
| CHEMBL144611 | — | — | 1 | 5.84 |
| CHEMBL144206 | — | — | 1 | 5.82 |
| CHEMBL147542 | — | — | 1 | 5.80 |
| CHEMBL357898 | — | — | 1 | 5.68 |
| CHEMBL147091 | — | — | 1 | 5.64 |
| CHEMBL432079 | — | — | 1 | 5.64 |
| CHEMBL144101 | — | — | 1 | 5.63 |
| CHEMBL144229 | — | — | 1 | 5.62 |
| CHEMBL424492 | — | — | 1 | 5.55 |
| CHEMBL355900 | — | — | 1 | 5.55 |
| CHEMBL344060 | — | — | 1 | 5.52 |
| CHEMBL343021 | — | — | 1 | 5.52 |
| CHEMBL144525 | — | — | 1 | 5.52 |
| CHEMBL145069 | — | — | 1 | 5.51 |
| CHEMBL342069 | — | — | 1 | 5.48 |
| CHEMBL147956 | — | — | 1 | 5.46 |
| CHEMBL147383 | — | — | 1 | 5.44 |
| CHEMBL146326 | — | — | 1 | 5.42 |
| CHEMBL357203 | — | — | 1 | 5.37 |
| CHEMBL358129 | — | — | 1 | 5.36 |
| CHEMBL145684 | — | — | 1 | 5.36 |
| CHEMBL342732 | — | — | 1 | 5.35 |
| CHEMBL357446 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344759 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL144780 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL144363 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL144293 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL144283 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL357414 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL356259 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL144611 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL144206 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL147542 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL357898 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL147091 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL432079 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL144101 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL144229 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL424492 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL355900 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL344060 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL343021 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL144525 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL145069 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL342069 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL147956 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL147383 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL146326 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL357203 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL145684 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL358129 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL342732 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL357446 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL148048 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL144736 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL357195 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL114427 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL145836 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL359217 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL147051 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL144021 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL144857 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL148331 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL147149 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL144001 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL344312 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL148395 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL148373 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL144568 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL144843 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL144188 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL29976 | — | IC50 | = | 8800.0 | nM | 5.06 |