Assay Detail
Binding
CHEMBL820053
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Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.59 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339943 | — | — | 1 | 8.54 |
| CHEMBL339532 | — | — | 1 | 8.17 |
| CHEMBL412732 | — | — | 1 | 7.96 |
| CHEMBL338798 | — | — | 1 | 7.96 |
| CHEMBL339073 | — | — | 1 | 7.57 |
| CHEMBL405308 | — | — | 1 | 7.55 |
| CHEMBL263432 | — | — | 1 | 7.38 |
| CHEMBL129274 | — | — | 1 | 6.89 |
| CHEMBL446683 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339943 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL339532 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL412732 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL338798 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL339073 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL405308 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL263432 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL129274 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL446683 | — | Ki | = | 490.0 | nM | 6.31 |