Assay Detail
Functional
CHEMBL820056
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In vitro antagonist activity was measured by inhibition of vasopressin-stimulated adenylate cyclase in renal medullary preparation in pig
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Renal medulla |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dicarbavasopressin antagonist analogues exhibit reduced in vivo agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.56 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372280 | — | — | 1 | 8.80 |
| CHEMBL2372281 | — | — | 1 | 8.54 |
| CHEMBL2372316 | — | — | 1 | 8.46 |
| CHEMBL2372291 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372280 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2372281 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL2372316 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2372291 | — | Ki | = | 3.6 | nM | 8.44 |