Assay Detail
Functional
CHEMBL820078
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Effective concentration against Xenopus oocytes expressing guinea pig heart Na channel
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 6-heterocyclic-substituted purines as inactivation modifiers of cardiac sodium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.39 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313277 | — | — | 1 | 7.07 |
| CHEMBL420045 | — | — | 1 | 7.00 |
| CHEMBL86653 | — | — | 1 | 6.80 |
| CHEMBL85548 | — | — | 1 | 6.80 |
| CHEMBL86779 | — | — | 1 | 6.69 |
| CHEMBL83511 | — | — | 1 | 6.40 |
| CHEMBL313247 | — | — | 1 | 6.28 |
| CHEMBL316233 | — | — | 1 | 6.24 |
| CHEMBL86574 | — | — | 1 | 6.24 |
| CHEMBL312932 | — | — | 1 | 6.23 |
| CHEMBL86679 | — | — | 1 | 6.20 |
| CHEMBL313815 | — | — | 1 | 6.10 |
| CHEMBL85345 | — | — | 1 | 5.99 |
| CHEMBL177786 | — | — | 1 | 5.90 |
| CHEMBL431485 | — | — | 1 | 5.85 |
| CHEMBL86860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313277 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL420045 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL86653 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL85548 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL86779 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL83511 | — | EC50 | = | 399.0 | nM | 6.40 |
| CHEMBL313247 | — | EC50 | = | 526.0 | nM | 6.28 |
| CHEMBL316233 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL86574 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL312932 | — | EC50 | = | 585.0 | nM | 6.23 |
| CHEMBL86679 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL313815 | — | EC50 | = | 796.0 | nM | 6.10 |
| CHEMBL85345 | — | EC50 | = | 1035.0 | nM | 5.99 |
| CHEMBL177786 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL431485 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL86860 | — | EC50 | > | 3000.0 | nM | - |