Assay Detail
Functional
CHEMBL820087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induced [Ca2+] influx in Vanilloid receptor subtype 1 expressing HEK 293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.21 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | 8.72 |
| CHEMBL18441 | — | — | 1 | 6.89 |
| CHEMBL18058 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL18441 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL18058 | — | EC50 | = | 935.0 | nM | 6.03 |