Assay Detail
Binding
CHEMBL820155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards alpha-adrenoceptor of calf cortex membrane Site B using [3H]-clonidine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Cerebral cortex alpha adrenergic receptor (CHEMBL2111420) ↗| Type | PROTEIN FAMILY |
| Organism | Bos taurus |
Publication
Synthesis and biological properties of thiophene ring analogues of mianserin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13645 | — | — | 1 | 8.52 |
| CHEMBL13644 | — | — | 1 | 8.52 |
| CHEMBL544428 | MIANSERIN HYDROCHLORIDE | -1.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13645 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL13644 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL544428 | MIANSERIN HYDROCHLORIDE | IC50 | = | 6.0 | nM | 8.22 |