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Assay Detail

CHEMBL820277

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Binding
Binding affinity for human Vasopressin V1a receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Vasopressin V1a receptor (CHEMBL1889)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors.
Terrillon S, Cheng LL, Stoev S, Mouillac B, Barberis C, Manning M, Durroux T.
J Med Chem (2002) 45 : 2579 -2588
PubMed 12036367 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.47 8.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1790712 1 8.41
CHEMBL1790723 1 8.12
CHEMBL1790719 1 7.93
CHEMBL1790720 1 7.91
CHEMBL1790717 1 7.86
CHEMBL1790729 1 7.76
CHEMBL1790728 1 7.59
CHEMBL1790711 1 7.52
CHEMBL1790718 1 7.24
CHEMBL1790721 1 6.97
CHEMBL395429 OXYTOCIN 4.0 1 6.92
CHEMBL1790713 1 6.66
CHEMBL1790722 1 6.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1790712 Ki = 3.9 nM 8.41
CHEMBL1790723 Ki = 7.6 nM 8.12
CHEMBL1790719 Ki = 11.8 nM 7.93
CHEMBL1790720 Ki = 12.2 nM 7.91
CHEMBL1790717 Ki = 13.7 nM 7.86
CHEMBL1790729 Ki = 17.3 nM 7.76
CHEMBL1790728 Ki = 25.5 nM 7.59
CHEMBL1790711 Ki = 30.0 nM 7.52
CHEMBL1790718 Ki = 57.0 nM 7.24
CHEMBL1790721 Ki = 107.0 nM 6.97
CHEMBL395429 OXYTOCIN Ki = 120.0 nM 6.92
CHEMBL1790713 Ki = 217.0 nM 6.66
CHEMBL1790722 Ki = 656.0 nM 6.18