Assay Detail
Binding
CHEMBL820283
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Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fluorescent pseudo-peptide linear vasopressin antagonists: design, synthesis, and applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.35 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540192 | — | — | 1 | 10.15 |
| CHEMBL269012 | — | — | 1 | 10.10 |
| CHEMBL412210 | — | — | 1 | 9.77 |
| CHEMBL430272 | — | — | 1 | 9.77 |
| CHEMBL429725 | — | — | 1 | 9.64 |
| CHEMBL262035 | — | — | 1 | 9.10 |
| CHEMBL407644 | — | — | 1 | 8.89 |
| CHEMBL268664 | — | — | 1 | 8.48 |
| CHEMBL410353 | — | — | 1 | 8.25 |
| CHEMBL409756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540192 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL269012 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL412210 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL430272 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL429725 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL262035 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL407644 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL268664 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL410353 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL409756 | — | Ki | > | 500.0 | nM | - |