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Assay Detail

CHEMBL820291

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of c-Jun N-terminal kinase 1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 8 (CHEMBL2276)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors.
Dumas J, Hatoum-Mokdad H, Sibley R, Riedl B, Scott WJ, Monahan MK, Lowinger TB, Brennan C, Natero R, Turner T, Johnson JS, Schoenleber R, Bhargava A, Wilhelm SM, Housley TJ, Ranges GE, Shrikhande A.
Bioorg Med Chem Lett (2000) 10 : 2051 -2054
PubMed 10999468 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.07 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64040 1 6.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64040 IC50 = 850.0 nM 6.07