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Assay Detail

CHEMBL820300

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of c-Jun N-terminal kinase 1-alpha 1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 8 (CHEMBL2276)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrroles and other heterocycles as inhibitors of p38 kinase.
de Laszlo SE, Visco D, Agarwal L, Chang L, Chin J, Croft G, Forsyth A, Fletcher D, Frantz B, Hacker C, Hanlon W, Harper C, Kostura M, Li B, Luell S, MacCoss M, Mantlo N, O'Neill EA, Orevillo C, Pang M, Parsons J, Rolando A, Sahly Y, Sidler K, O'Keefe SJ.
Bioorg Med Chem Lett (1998) 8 : 2689 -2694
PubMed 9873604 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.80 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL88486 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL88486 IC50 = 16000.0 nM 4.80