Assay Detail
Binding
CHEMBL820306
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Inhibition of c-Jun N-terminal kinase 2-alpha 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.68 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69331 | — | — | 1 | 7.54 |
| CHEMBL68572 | — | — | 1 | 7.01 |
| CHEMBL69228 | — | — | 1 | 6.89 |
| CHEMBL67874 | — | — | 1 | 6.85 |
| CHEMBL67633 | — | — | 1 | 6.76 |
| CHEMBL302728 | — | — | 1 | 6.75 |
| CHEMBL63135 | — | — | 1 | 6.71 |
| CHEMBL69764 | — | — | 1 | 6.68 |
| CHEMBL446404 | — | — | 1 | 6.53 |
| CHEMBL307435 | — | — | 1 | 6.52 |
| CHEMBL67658 | — | — | 1 | 6.04 |
| CHEMBL302805 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69331 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL68572 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL69228 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL67874 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL67633 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL302728 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL63135 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL69764 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL446404 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL307435 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL67658 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL302805 | — | IC50 | = | 1420.0 | nM | 5.85 |