Assay Detail
Binding
CHEMBL820357
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Inhibition of integrin alpha4-beta7 adhesion to JY cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JY |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.01 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88478 | — | — | 1 | 5.70 |
| CHEMBL369635 | — | — | 1 | 5.10 |
| CHEMBL173552 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88478 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL369635 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL173552 | — | IC50 | = | 59000.0 | nM | 4.23 |