Assay Detail
Binding
CHEMBL820361
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Inhibitory activity of compound against alpha4-beta7 integrin using MAdCAM-Ig ligand
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Amidines as amide bond replacements in VLA-4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.23 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74437 | — | — | 1 | 8.66 |
| CHEMBL74958 | — | — | 1 | 8.39 |
| CHEMBL76119 | — | — | 1 | 7.96 |
| CHEMBL309823 | — | — | 1 | 7.85 |
| CHEMBL310044 | — | — | 1 | 7.80 |
| CHEMBL420936 | — | — | 1 | 7.72 |
| CHEMBL75032 | — | — | 1 | 7.68 |
| CHEMBL306827 | — | — | 1 | 7.57 |
| CHEMBL312369 | — | — | 1 | 7.46 |
| CHEMBL407284 | — | — | 1 | 7.46 |
| CHEMBL305709 | — | — | 1 | 7.40 |
| CHEMBL74507 | — | — | 1 | 7.37 |
| CHEMBL308155 | — | — | 1 | 7.19 |
| CHEMBL74727 | — | — | 1 | 7.16 |
| CHEMBL78157 | — | — | 1 | 7.11 |
| CHEMBL74321 | — | — | 1 | 7.11 |
| CHEMBL309088 | — | — | 1 | 7.01 |
| CHEMBL407381 | — | — | 1 | 6.92 |
| CHEMBL77623 | — | — | 1 | 5.52 |
| CHEMBL414879 | — | — | 1 | 5.39 |
| CHEMBL308124 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74437 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL74958 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL76119 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL309823 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL310044 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL420936 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL75032 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL306827 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL312369 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL407284 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL305709 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL74507 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL308155 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL74727 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL78157 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL74321 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL309088 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL407381 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL77623 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL414879 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL308124 | — | IC50 | = | 8400.0 | nM | 5.08 |