Assay Detail
Binding
CHEMBL820515
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Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of buffer
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.24 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34964 | — | — | 1 | 6.52 |
| CHEMBL1160008 | IODOPHTHALEIN | 2.0 | 1 | 5.30 |
| CHEMBL298301 | — | — | 1 | 5.22 |
| CHEMBL48760 | — | — | 1 | 5.16 |
| CHEMBL34712 | — | — | 1 | 4.92 |
| CHEMBL46666 | — | — | 1 | 4.82 |
| CHEMBL1160160 | ROSE BENGAL | — | 1 | 4.72 |
| CHEMBL429694 | CONGO RED | -1.0 | 1 | - |
| CHEMBL34034 | — | — | 1 | - |
| CHEMBL285527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34964 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1160008 | IODOPHTHALEIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL298301 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL48760 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL34712 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL46666 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1160160 | ROSE BENGAL | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL429694 | CONGO RED | IC50 | = | 340000.0 | nM | - |
| CHEMBL34034 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL285527 | — | IC50 | > | 1600000.0 | nM | - |