Assay Detail
Binding
CHEMBL820579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human c-Raf kinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.02 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431583 | — | — | 1 | 6.50 |
| CHEMBL10 | SB-203580 | — | 1 | 6.48 |
| CHEMBL303144 | — | — | 1 | 6.09 |
| CHEMBL67658 | — | — | 1 | 5.58 |
| CHEMBL308939 | — | — | 1 | 5.46 |
| CHEMBL305178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431583 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL10 | SB-203580 | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL303144 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL67658 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL308939 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL305178 | — | IC50 | > | 1000.0 | nM | - |