Assay Detail
Functional
CHEMBL820597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assay
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.18 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148169 | — | — | 2 | 9.46 |
| CHEMBL148351 | — | — | 1 | 8.65 |
| CHEMBL342076 | — | — | 1 | 8.23 |
| CHEMBL436071 | — | — | 2 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148169 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL148351 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL342076 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL436071 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL436071 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL148169 | — | IC50 | = | 350.0 | nM | 6.46 |