Assay Detail
Binding
CHEMBL820677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of trypsin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.08 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100989 | — | — | 1 | 10.70 |
| CHEMBL99622 | — | — | 1 | 9.92 |
| CHEMBL101041 | — | — | 1 | 9.30 |
| CHEMBL101030 | — | — | 1 | 9.22 |
| CHEMBL102081 | — | — | 1 | 8.70 |
| CHEMBL102115 | — | — | 1 | 7.58 |
| CHEMBL318001 | — | — | 1 | 7.48 |
| CHEMBL323543 | — | — | 1 | 7.40 |
| CHEMBL100672 | — | — | 1 | 7.39 |
| CHEMBL457155 | — | — | 1 | 7.16 |
| CHEMBL323544 | — | — | 1 | 6.66 |
| CHEMBL102134 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100989 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL99622 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL101041 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL101030 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL102081 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL102115 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL318001 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL323543 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL100672 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL457155 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL323544 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL102134 | — | IC50 | = | 3300.0 | nM | 5.48 |