Assay Detail
Binding
CHEMBL820698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGF receptor 2 mediated phosphorylation of poly-Glu/Tyr (4:1)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.98 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333297 | — | — | 1 | 8.40 |
| CHEMBL119276 | — | — | 1 | 8.40 |
| CHEMBL324489 | — | — | 1 | 8.30 |
| CHEMBL117052 | — | — | 1 | 8.30 |
| CHEMBL119552 | — | — | 1 | 8.30 |
| CHEMBL325003 | — | — | 1 | 8.22 |
| CHEMBL118569 | — | — | 1 | 8.15 |
| CHEMBL221736 | — | — | 1 | 8.10 |
| CHEMBL118748 | — | — | 1 | 8.10 |
| CHEMBL117983 | — | — | 1 | 8.00 |
| CHEMBL118832 | — | — | 1 | 7.96 |
| CHEMBL420528 | — | — | 1 | 7.85 |
| CHEMBL323838 | — | — | 1 | 7.80 |
| CHEMBL118440 | — | — | 1 | 7.35 |
| CHEMBL327029 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333297 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL119276 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL324489 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL117052 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL119552 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL325003 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL118569 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL221736 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL118748 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL117983 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL118832 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL420528 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL323838 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL118440 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL327029 | — | IC50 | = | 355.0 | nM | 6.45 |