Assay Detail
Functional
CHEMBL820777
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Inhibition of tubulin polymerization
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.91 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.34 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.28 |
| CHEMBL51928 | — | — | 1 | 6.28 |
| CHEMBL50666 | — | — | 1 | 6.26 |
| CHEMBL48300 | — | — | 1 | 6.20 |
| CHEMBL52342 | — | — | 1 | 6.18 |
| CHEMBL49827 | — | — | 1 | 6.14 |
| CHEMBL295291 | — | — | 1 | 6.13 |
| CHEMBL51408 | — | — | 1 | 6.11 |
| CHEMBL49835 | — | — | 1 | 6.11 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.10 |
| CHEMBL51139 | — | — | 1 | 6.05 |
| CHEMBL51998 | — | — | 1 | 6.03 |
| CHEMBL105469 | — | — | 1 | 6.00 |
| CHEMBL423845 | — | — | 1 | 5.96 |
| CHEMBL45677 | — | — | 1 | 5.82 |
| CHEMBL49016 | — | — | 1 | 5.82 |
| CHEMBL48330 | — | — | 1 | 5.75 |
| CHEMBL317272 | — | — | 1 | 5.75 |
| CHEMBL45620 | — | — | 1 | 5.72 |
| CHEMBL50866 | — | — | 1 | 5.68 |
| CHEMBL102019 | — | — | 1 | 5.64 |
| CHEMBL48541 | — | — | 1 | 5.60 |
| CHEMBL299979 | — | — | 1 | 5.48 |
| CHEMBL48779 | — | — | 1 | 5.29 |
| CHEMBL298328 | — | — | 1 | 4.85 |
| CHEMBL440887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL51928 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL50666 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL48300 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL52342 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL49827 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL295291 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL51408 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL49835 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL107 | COLCHICINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL51139 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL51998 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL105469 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL423845 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL45677 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL49016 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL48330 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL317272 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL45620 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL50866 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL102019 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL48541 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL299979 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL48779 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL298328 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL440887 | — | IC50 | > | 40000.0 | nM | - |