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Assay Detail

CHEMBL820799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Melanophore aggregation of the dermal melanocytes of Xenopus laevis tadpoles
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors.
Jellimann C, Mathé-Allainmat M, Andrieux J, Kloubert S, Boutin JA, Nicolas JP, Bennejean C, Delagrange P, Langlois M.
J Med Chem (2000) 43 : 4051 -4062
PubMed 11063602 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 8.83 10.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL336509 1 10.60
CHEMBL131252 1 10.10
CHEMBL132802 1 10.00
CHEMBL129890 1 9.74
CHEMBL130214 1 9.34
CHEMBL10878 AGOMELATINE 4.0 1 9.28
CHEMBL131424 1 8.79
CHEMBL130898 1 8.58
CHEMBL130490 1 8.29
CHEMBL337882 1 7.58
CHEMBL336647 1 7.24
CHEMBL132340 1 6.37
CHEMBL340832 1 -
CHEMBL130286 1 -
CHEMBL130203 1 -
CHEMBL131602 1 -
CHEMBL337295 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL336509 EC50 = 0.025 nM 10.60
CHEMBL131252 EC50 = 0.08 nM 10.10
CHEMBL132802 EC50 = 0.1 nM 10.00
CHEMBL129890 EC50 = 0.18 nM 9.74
CHEMBL130214 EC50 = 0.46 nM 9.34
CHEMBL10878 AGOMELATINE EC50 = 0.53 nM 9.28
CHEMBL131424 EC50 = 1.61 nM 8.79
CHEMBL130898 EC50 = 2.65 nM 8.58
CHEMBL130490 EC50 = 5.08 nM 8.29
CHEMBL337882 EC50 = 26.0 nM 7.58
CHEMBL336647 EC50 = 57.8 nM 7.24
CHEMBL132340 EC50 = 428.0 nM 6.37
CHEMBL340832 EC50 = 0.004 nM -
CHEMBL130286 EC50 > 1000.0 nM -
CHEMBL130203 EC50 > 1000.0 nM -
CHEMBL131602 EC50 > 1000.0 nM -
CHEMBL337295 EC50 > 1000.0 nM -