Assay Detail
Binding
CHEMBL820845
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Inhibition of human recombinant cyclin D2-CDK4
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.12 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143748 | — | — | 1 | 8.80 |
| CHEMBL336242 | — | — | 1 | 8.64 |
| CHEMBL140216 | — | — | 1 | 7.68 |
| CHEMBL140781 | — | — | 1 | 7.54 |
| CHEMBL344031 | — | — | 1 | 7.25 |
| CHEMBL140141 | — | — | 1 | 7.19 |
| CHEMBL356535 | — | — | 1 | 6.89 |
| CHEMBL143361 | — | — | 1 | 6.80 |
| CHEMBL359020 | — | — | 1 | 6.68 |
| CHEMBL143285 | — | — | 1 | 6.66 |
| CHEMBL342336 | — | — | 1 | 6.60 |
| CHEMBL140205 | — | — | 1 | 6.54 |
| CHEMBL140670 | — | — | 1 | 6.33 |
| CHEMBL143163 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143748 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL336242 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL140216 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL140781 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL344031 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL140141 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL356535 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL143361 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL359020 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL143285 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL342336 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL140205 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL140670 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL143163 | — | IC50 | = | 720.0 | nM | 6.14 |