Assay Detail
Binding
CHEMBL820884
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Tested for inhibition of [3H]LVP binding to vasopressin receptor in medullary membranes of pig kidney.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel vasopressin analogues that help define a minimum effective antagonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.78 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408474 | — | — | 1 | 8.34 |
| CHEMBL262423 | — | — | 1 | 7.92 |
| CHEMBL216606 | — | — | 1 | 7.92 |
| CHEMBL405818 | — | — | 1 | 7.72 |
| CHEMBL416114 | — | — | 1 | 7.58 |
| CHEMBL264540 | — | — | 1 | 7.52 |
| CHEMBL262499 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408474 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL262423 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL216606 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL405818 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL416114 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL264540 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL262499 | — | Ki | = | 37.0 | nM | 7.43 |