Assay Detail
Binding
CHEMBL820885
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Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel vasopressin analogues that help define a minimum effective antagonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.30 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408474 | — | — | 1 | 8.92 |
| CHEMBL262423 | — | — | 1 | 8.41 |
| CHEMBL416114 | — | — | 1 | 8.24 |
| CHEMBL216606 | — | — | 1 | 8.19 |
| CHEMBL405818 | — | — | 1 | 8.17 |
| CHEMBL264540 | — | — | 1 | 8.14 |
| CHEMBL262499 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408474 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL262423 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL416114 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL216606 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL405818 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL264540 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL262499 | — | Ki | = | 9.4 | nM | 8.03 |