Assay Detail
Binding
CHEMBL820893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of radioligand [3H]AVP binding to V1 receptor in rat liver plasma membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Plasma Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 8.69 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384292 | — | — | 1 | 9.66 |
| CHEMBL438387 | — | — | 1 | 9.49 |
| CHEMBL265264 | — | — | 1 | 9.23 |
| CHEMBL411420 | — | — | 1 | 9.21 |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 9.19 |
| CHEMBL265017 | — | — | 1 | 9.02 |
| CHEMBL330022 | — | — | 1 | 8.70 |
| CHEMBL274397 | — | — | 1 | 8.42 |
| CHEMBL414582 | — | — | 1 | 8.08 |
| CHEMBL1793955 | — | — | 1 | 8.08 |
| CHEMBL415230 | — | — | 1 | 7.88 |
| CHEMBL87636 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384292 | — | Kd | = | 0.22 | nM | 9.66 |
| CHEMBL438387 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL265264 | — | Kd | = | 0.59 | nM | 9.23 |
| CHEMBL411420 | — | Kd | = | 0.62 | nM | 9.21 |
| CHEMBL373742 | VASOPRESSIN | Kd | = | 0.65 | nM | 9.19 |
| CHEMBL265017 | — | Kd | = | 0.96 | nM | 9.02 |
| CHEMBL330022 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL274397 | — | Kd | = | 3.8 | nM | 8.42 |
| CHEMBL414582 | — | Kd | = | 8.28 | nM | 8.08 |
| CHEMBL1793955 | — | Kd | = | 8.28 | nM | 8.08 |
| CHEMBL415230 | — | Kd | = | 13.1 | nM | 7.88 |
| CHEMBL87636 | — | Kd | = | 50.1 | nM | 7.30 |