Assay Detail
Binding
CHEMBL820958
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Displacement of [3H]RTX binding from vanilloid receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.22 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | 7.64 |
| CHEMBL285922 | — | — | 1 | 7.18 |
| CHEMBL27105 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL285922 | — | Ki | = | 66.1 | nM | 7.18 |
| CHEMBL27105 | — | Ki | = | 149.0 | nM | 6.83 |