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Assay Detail

CHEMBL820964

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested in vitro for the cytotoxic activity against uninfected Vero cells
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Intermediate

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

The synthesis and anti-hiv activity of pyrimidine dioxolanyl nucleosides
Wilson LJ, Choi W, Spurling T, Liotta DC, Schinazi RF, Cannon D, Painter GR, St. Clair M, Furman PA
Bioorg Med Chem Lett (1993) 3 : 169 -174
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.20 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300793 1 6.77
CHEMBL505733 3 6.52
CHEMBL46089 1 -
CHEMBL61323 1 -
CHEMBL45897 1 -
CHEMBL297319 1 -
CHEMBL2115444 1 -
CHEMBL292278 1 -
CHEMBL301947 1 -
CHEMBL49561 1 -
CHEMBL303553 1 -
CHEMBL2115443 1 -
CHEMBL46090 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300793 IC50 = 170.0 nM 6.77
CHEMBL505733 IC50 = 300.0 nM 6.52
CHEMBL505733 IC50 = 660.0 nM 6.18
CHEMBL505733 IC50 = 4600.0 nM 5.34
CHEMBL46089 IC50 > 100000.0 nM -
CHEMBL61323 IC50 > 100000.0 nM -
CHEMBL45897 IC50 > 100000.0 nM -
CHEMBL297319 IC50 > 100000.0 nM -
CHEMBL2115444 IC50 > 100000.0 nM -
CHEMBL292278 IC50 > 100000.0 nM -
CHEMBL301947 IC50 > 100000.0 nM -
CHEMBL49561 IC50 > 100000.0 nM -
CHEMBL303553 IC50 > 100000.0 nM -
CHEMBL2115443 IC50 > 100000.0 nM -
CHEMBL46090 IC50 > 100000.0 nM -