Assay Detail
Binding
CHEMBL821055
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Inhibition of [125I]MAdCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8866 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.09 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91485 | — | — | 1 | 9.12 |
| CHEMBL76119 | — | — | 1 | 7.97 |
| CHEMBL56511 | — | — | 1 | 7.94 |
| CHEMBL309823 | — | — | 1 | 7.85 |
| CHEMBL91877 | — | — | 1 | 7.28 |
| CHEMBL313632 | — | — | 1 | 7.11 |
| CHEMBL90198 | — | — | 1 | 7.01 |
| CHEMBL91031 | — | — | 1 | 6.17 |
| CHEMBL88478 | — | — | 1 | 6.06 |
| CHEMBL93638 | — | — | 1 | 6.02 |
| CHEMBL278045 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91485 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL76119 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL56511 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL309823 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL91877 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL313632 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL90198 | — | IC50 | = | 97.1 | nM | 7.01 |
| CHEMBL91031 | — | IC50 | = | 669.9 | nM | 6.17 |
| CHEMBL88478 | — | IC50 | = | 862.0 | nM | 6.06 |
| CHEMBL93638 | — | IC50 | = | 948.8 | nM | 6.02 |
| CHEMBL278045 | — | IC50 | = | 3551.1 | nM | 5.45 |