Assay Detail
Binding
CHEMBL821111
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Inhibitory activity against arginine vasopressin V1 receptor using [3H]AVP as radioligand in rat liver
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
New analgesic drugs derived from phencyclidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.06 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368462 | — | — | 1 | 6.96 |
| CHEMBL175813 | — | — | 1 | 6.54 |
| CHEMBL176264 | — | — | 1 | 6.52 |
| CHEMBL175211 | — | — | 1 | 6.41 |
| CHEMBL368791 | — | — | 1 | 6.32 |
| CHEMBL175930 | — | — | 1 | 6.02 |
| CHEMBL441498 | — | — | 1 | 5.72 |
| CHEMBL369712 | — | — | 1 | 5.70 |
| CHEMBL175411 | — | — | 1 | 5.68 |
| CHEMBL177556 | — | — | 1 | 5.50 |
| CHEMBL420762 | MOZAVAPTAN | 4.0 | 1 | 5.30 |
| CHEMBL360272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368462 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL175813 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL176264 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL175211 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL368791 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL175930 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL441498 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL369712 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL175411 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL177556 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL420762 | MOZAVAPTAN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL360272 | — | IC50 | > | 10000.0 | nM | - |