Assay Detail
Binding
CHEMBL821114
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Compound was evaluated for its dissociation constant (Kd) to rat liver Vasopressin V1 receptor
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of oxytocin antagonists containing conformationally constrained amino acids in position 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.03 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 9.19 |
| CHEMBL264208 | — | — | 1 | 8.42 |
| CHEMBL2371240 | — | — | 2 | 7.75 |
| CHEMBL157988 | — | — | 1 | 7.30 |
| CHEMBL405165 | — | — | 1 | 6.05 |
| CHEMBL2110297 | — | — | 1 | 5.58 |
| CHEMBL2110163 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | Kd | = | 0.65 | nM | 9.19 |
| CHEMBL264208 | — | Kd | = | 3.8 | nM | 8.42 |
| CHEMBL2371240 | — | Kd | = | 17.8 | nM | 7.75 |
| CHEMBL157988 | — | Kd | = | 50.1 | nM | 7.30 |
| CHEMBL2371240 | — | Kd | = | 63.5 | nM | 7.20 |
| CHEMBL405165 | — | Kd | = | 888.0 | nM | 6.05 |
| CHEMBL2110297 | — | Kd | = | 2640.0 | nM | 5.58 |
| CHEMBL2110163 | — | Kd | = | 17600.0 | nM | 4.75 |