Assay Detail
Binding
CHEMBL821136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285913 | TREQUINSIN | 2.0 | 1 | 5.30 |
| CHEMBL32727 | — | — | 1 | - |
| CHEMBL35893 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285913 | TREQUINSIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL32727 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL35893 | — | IC50 | = | 195000.0 | nM | - |