Assay Detail
Functional
CHEMBL821150
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Compound was tested for inhibition of human W1L2 cell growth.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WIL2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.37 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35926 | — | — | 1 | 7.14 |
| CHEMBL30179 | — | — | 1 | 6.66 |
| CHEMBL34857 | — | — | 1 | 6.51 |
| CHEMBL35941 | — | — | 1 | 6.48 |
| CHEMBL37106 | — | — | 1 | 6.46 |
| CHEMBL287693 | — | — | 1 | 6.43 |
| CHEMBL264609 | — | — | 1 | 6.36 |
| CHEMBL288615 | — | — | 1 | 6.33 |
| CHEMBL36721 | — | — | 1 | 6.30 |
| CHEMBL289749 | — | — | 1 | 6.20 |
| CHEMBL291084 | — | — | 1 | 6.19 |
| CHEMBL36433 | — | — | 1 | 6.10 |
| CHEMBL36426 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35926 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL30179 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL34857 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL35941 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL37106 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL287693 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL264609 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL288615 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL36721 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL289749 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL291084 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL36433 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL36426 | — | IC50 | = | 2300.0 | nM | 5.64 |