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Assay Detail

CHEMBL821153

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibitory activity against human lymphoblastoid W1L2 cell line in presence of 10 uM thymidine/50 uM hypoxanthine
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type WIL2
Confidence 1 — Organism
Curated By Expert

Target

WIL2 (CHEMBL612809)
Type CELL-LINE
Organism Homo sapiens

Publication

The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.
Bavetsias V, Skelton LA, Yafai F, Mitchell F, Wilson SC, Allan B, Jackman AL.
J Med Chem (2002) 45 : 3692 -3702
PubMed 12166942 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.15 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL68216 1 9.15
CHEMBL122506 1 9.11
CHEMBL444334 1 8.64
CHEMBL122748 1 8.27
CHEMBL123191 1 8.15
CHEMBL332428 1 8.13
CHEMBL122897 1 8.08
CHEMBL332517 1 8.02
CHEMBL333693 1 7.85
CHEMBL124240 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL68216 IC50 = 0.7 nM 9.15
CHEMBL122506 IC50 = 0.78 nM 9.11
CHEMBL444334 IC50 = 2.3 nM 8.64
CHEMBL122748 IC50 = 5.4 nM 8.27
CHEMBL123191 IC50 = 7.1 nM 8.15
CHEMBL332428 IC50 = 7.4 nM 8.13
CHEMBL122897 IC50 = 8.4 nM 8.08
CHEMBL332517 IC50 = 9.6 nM 8.02
CHEMBL333693 IC50 = 14.0 nM 7.85
CHEMBL124240 IC50 = 800.0 nM 6.10