Assay Detail
Functional
CHEMBL821154
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Growth inhibitory activity against human lymphoblastoid W1L2 cell line in presence of 10 uM thymidine/50 uM hypoxanthine
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WIL2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.11 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123756 | — | — | 1 | 9.49 |
| CHEMBL120872 | — | — | 1 | 9.14 |
| CHEMBL124171 | — | — | 1 | 9.12 |
| CHEMBL333094 | — | — | 1 | 9.11 |
| CHEMBL333876 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123756 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL120872 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL124171 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL333094 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL333876 | — | IC50 | = | 2.0 | nM | 8.70 |